Published on: Mar 14, 2017 at UC Davis Comprehensive Cancer Center

Faulty DNA error correction genes set stage for familial gastric cancer

By : UC Davis Comprehensive Cancer Center

Published in the Gastroenterology Journal, UC Davis researchers have identified genetic variations that contribute to familial gastric cancer. Inherited mutations – which affect the PALB2, BRCA1 and RAD51C genes and have been implicated in other cancer types – impair a critical DNA repair mechanism called homologous recombination. These findings could improve preventive care and new gastric cancer therapies.

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